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Inserm Transfert ht29 mtx cell line
Ht29 Mtx Cell Line, supplied by Inserm Transfert, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ht29-mtx+cell+line/cells+ht29+mtx/pm39207115-40-16-27
Average 86 stars, based on 1 article reviews
ht29 mtx cell line - by Bioz Stars, 2026-09
86/100 stars

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Article Title: ZnO Nanoparticles Affect Nutrient Transport in an In Vitro Model of the Small Intestine
Article Snippet: The HT29-MTX cell line was provided by Dr. Thecla Lesuffleur of INSERM U560 in Lille, France, at Passage 11 and used in experiments at Passage 18-33 ( Lesuffleur et al., 1990 ).

Article Title: Effect of uremic state in intestine through a co-culture in vitro intestinal epithelial model.
Article Snippet: The progressive loss of renal function in chronic kidney disease (CKD) leads to the accumulation of uremic toxins.. Recent studies related uremic plasma as well dysbiotic gut microbiome to impaired intestinal barrier function, allowing the translocation of microorganisms or by-products from the intestinal lumen to systemic circulation, contributing to systemic inflammation, cardiovascular risk and progression of CKD.. Our main goal was to evaluate the impact of different uremic conditions on an improved in vitro intestinal Caco-2/HT29-MTX/ Raji B triple co-culture model. For that, the impact of CKD patients’ plasma and elevated urea concentration and its by-products on the triple model was assessed.

Article Title: Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol.
Article Snippet: Nanoparticles based on gellan gum/pectin blends were designed for colon-targeted release of resveratrol (RES).. Their impact on drug release rates and permeability were evaluated using Caco-2 cell model and mucus secreting triple co-culture model. Polymeric nanoparticles (PNP) were successfully prepared by nebulization/ionotropic gelation, achieving high drug loading (>80%).. PNP were spherical with a low positive charge density (+5mV) and exhibited diameters of around 330nm.

Article Title: Towards personalized drug delivery via semi-solid extrusion: Exploring poly(vinyl alcohol-co-vinyl acetate) copolymers for hydrochlorothiazide-loaded films.
Article Snippet: HT29-MTX cell line was kindly provided by Dr. Thécla Lesuffleur (INSERM UMR S 938, FR).

Article Title: Prediction of the enhanced insulin absorption across a triple co-cultured intestinal model using mucus penetrating PLGA nanoparticles.
Article Snippet: Insulin is a protein macromolecule used to treat diabetes mellitus.. Currently, insulin requires multiple daily subcutaneous (SC) injections to control blood sugar in diabetics.. Thus, reducing the patients’ compliance and adherence to medication as SC route is invasive.

Article Title: Water-soluble chitosan eases development of mucoadhesive buccal films and wafers for children.
Article Snippet: The HT29-MTX cell line was kindly provided by Dr. Thécla Lesuffleur (INSERM UMR S 938, France).

Article Title: Hydroxytyrosol encapsulated in biocompatible water-in-oil microemulsions: How the structure affects in vitro absorption.
Article Snippet: Over the last years, the incorporation of natural antioxidants in food and pharmaceutical formulations has gained attention, delaying or preventing oxidation phenomena in the final products.. In order to take full advantage of their properties, protection in special microenvironments is of great importance.. The unique features of the natural phenolic compound hydroxytyrosol (HT) including antioxidant, anti-inflammatory, antiproliferative and cardioprotective properties have been studied to clarify its mechanism of action.

Article Title: Small silica nanoparticles transiently modulate the intestinal permeability by actin cytoskeleton disruption in both Caco-2 and Caco-2/HT29-MTX models.
Article Snippet: Amorphous silica nanoparticles are widely used as pharmaceutical excipients and food additive (E551).. Despite the potential human health risks of mineral nanoparticles, very few data regarding their oral toxicity are currently available.. This study aims to evaluate and to understand the interactions of silica particles at 1 and 10 mg mL−1 with the intestinal barrier using a Caco-2 monolayer and a Caco-2/HT29-MTX co-culture.



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Summary of outcomes of the toxicological testing of the NMs in this study

Journal: Archives of Toxicology

Article Title: Evaluation of the cyto- and genotoxicity of two types of cellulose nanomaterials using human intestinal cells and in vitro digestion simulation

doi: 10.1007/s00204-024-03911-2

Figure Lengend Snippet: Summary of outcomes of the toxicological testing of the NMs in this study

Article Snippet: Two human intestinal cell lines—Caco-2 and HT29-MTX-E12 cell lines (European Collection of Authenticated Cell Cultures, ECACC, Salisbury, UK), were selected as experimental models for in vitro studies.

Techniques: MTT Assay, Alkaline Single Cell Gel Electrophoresis, Single Cell Gel Electrophoresis, Mutagenesis